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Promethazine with Codeine Oral Option needs to be employed with warning in sufferers with bone-marrow melancholy. Leukopenia and agranulocytosis have been reported, normally when promethazine has long been used in Affiliation with other identified marrow-toxic brokers.
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The narcotic antagonist, naloxone hydrochloride, could possibly be administered when important respiratory despair takes place with promethazine and codeine; any depressant effects of promethazine will not be reversed with naloxone. Diazepam may be employed to control convulsions. Stay away from analeptics, which may bring about convulsions. Acidosis and electrolyte losses needs to be corrected. An increase in temperature or pulmonary difficulties may perhaps sign the necessity for establishment of antibiotic therapy.
Codeine has long been described to show no proof of carcinogenicity or mutagenicity in a variety of take a look at methods, such as the micronucleus and sperm abnormality assays plus the Salmonella assay. Promethazine was nonmutagenic inside the Salmonella examination method of Ames.
Stimulation might be obvious, specifically in little ones and geriatric people. Convulsions may perhaps not often take place. A paradoxical-sort reaction has actually been described in small children acquiring one doses of 75 mg to a hundred twenty five mg orally, characterised by promethazine codein for sale hyperexcitability and nightmares.
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